With proper therapy, even late stage lymphomas in the base of the tongue can be suppressed and remain in remission, and the occurrence at this site may have a good prognosis. Am J Hematol. Before D. L. Harsany, J. Ross, and W. E. Fee, Follicular lymphoid hyperplasia of the hard palate simulating lymphoma, OtolaryngologyHead and Neck Surgery, vol. The patient received two cycles of GDP (gemcitabine, dexamethasone, cisplatin) and seven cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy. Extranodal lymphomas of the head and neck. Am J Surg Pathol. Saxman S, Righi P. Mantle cell lymphoma appearing as a tongue base mass. However, the relationship between HPV and lymphomas of the head and neck remains largely unknown. 2015;390:31537. Google Scholar. Mohd Ridah LJ, A Talib N, Muhammad N, Hussain FA, Zainuddin N. p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia. Four treatment response classes were defined, as follows: complete response (CR, 100% resolution); partial response (PR, 50100% resolution); no response (<50% resolution); and progression of disease (PD, tumour enlarged after treatment). Peripheral T-cell lymphoma mimicking marginal zone B-cell lymphoma. Bookshelf PubMedGoogle Scholar. In the middle power view, there were plenty of moderate to large cells with distorted nuclear contours (Fig. Yuen A, Jacobs C. Lymphomas of the head and neck. d. Tumour cells diffusely expressed CD3 (200x). Bratisl Lek Listy. The appearance of brown punctate dots in the tumour cell nucleus or cytoplasm was considered positive. 2018 Aug;275(8):1945-1953. doi: 10.1007/s00405-018-5041-1. d. Tumour cells were positive for C-myc (200 x). St. Louis, MO: Elsevier; 2016. [27], which comprised 9 cases of GC and 4 cases of NGC. Federal government websites often end in .gov or .mil. None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. The HPV subtype that often infected the cervix, were active but doesnt do much harm to the host because the oral area was not the best breeding site for the virus. https://doi.org/10.1093/annonc/mdl131. Cancer that develops in the base of the tongue is a type of head and neck cancer. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. Only one widely disseminated case has been referenced, which involved cervical nodes, major salivary glands, orbits, and mediastinum [4]. Then he looked down my throat through my nose. Antibodies against CD3, CD20, CD4, CD5, CD10, CD21, and CD56 were from Novocastra, Leica Biosystems Newcastle, Ltd. Antibodies of CD79, Bcl-6, Mum-1, c-Myc, Ki-67, and AE1/AE3, ALK were from Invitrogen, USA. [2], A lymph node is small, capsulated lymphoid organ that is present along the lymphatic system. Bone marrow involvement was identified at relapse. Lymphoma is the second most common primary malignancy occurring in the head and neck behind squamous cell carcinoma, while NHL accounts for 6590% of all lymphomas occurring in the head and neck [1, 2] .2030% of NHLs are derived from extra-nodal sites [3] .Nonetheless, NHL with a primary site in the oral cavity is rare, and in the tongue base, even rarer [4, 5]. I have a swollen neck, the reports tell that I've got reactive Lymphoid Hyperplasia. Open tracheotomy was performed on POD 3 due to the absence of a leak, and biopsies were again performed, which ultimately revealed the equivalent benign pathologic findings. 2017;18:27815. An official website of the United States government. Before Tumour cell morphologies were different for each case, but all of the tumour cells expressed T cell markers, such as CD3, CD4, and CD8. Co. Ltd., China. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. The most common subtype of NHLs of the tongue base is DLBCL, and the occurrence at this site may have a good prognosis. Google Scholar. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. Arch Pathol Lab Med. 1993;189:30011. Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. https://doi.org/10.1016/j.leukres.2005.11.004. 1. However, this index markedly increases to 4% (4/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. One patient in the literature died 18months after diagnosis despite being in an early stage. All cases were negative for EBV ISH but one case was positive for HPV DNA ISH while the other six cases were negative for HPV DNA ISH. The most common site for all cases was at the base of the tongue. For the in situ detection of high-risk HPV integration at the mRNA level, the RNAscope FFPE 2.5 HD detection kit (Brown) (CAT #322310) was used according to the manufacturers instructions. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. [Diagnostics of laryngopharyngeal form of gastroesophageal reflux disease for adults (Lithuanian clinical practice guidelines)]. Mamede RC, Amaral Fd, Raimundo DG, Freitas LC, Ricz HM, Mello Filho FV. As they mount an immune response, lymphoid cells can proliferate and enlarge. 2008;88:2068. e. HPV DNA ISH showed brown punctate dots in the tumour cell nucleus or cytoplasm (400x).f. Spectrum of a benign entity. Bookshelf 3). Jrvenp P, Ilmarinen T, Geneid A, Pietarinen P, Kinnari TJ, Rihkanen H, Ruohoalho J, Markkanen-Leppnen M, Bck L, Arkkila P, Aaltonen LM. https://doi.org/10.1038/modpathol.2016.152. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. Article Article Antibodies against CD8, CD23, CD43, Bcl-2, and CyclinD1 were from Dako, Glostrup, Denmark. All 7 lymphomas were localized at the base of the tongue. Semin Oncol. Video chat with a U.S. board-certified doctor 24/7 in a minute. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. HPV is considered to be associated with the occurrence of oropharyngeal squamous cell carcinoma [8], therefore, we detected the infection status of the the two viruses in lymphoma of the base of the tongue. HIV serology was negative. Manage cookies/Do not sell my data we use in the preference centre. Imaging examination can help identify lesions. The condition mainly affects adult patients, ranging. Copyright 2011 Noah B. Sands and Marc Tewfik. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. When the lymphoid tissue is deeply seated, the appearance may be more pink or deeper in color. Depending upon the location of the RLH, the appearance of tissue may vary. Two patients, including our patient, died during follow-up. f. Tumour cells were negative for CD8 (200x). It is composed of cortex and medulla. Common symptoms reported by people with benign lymphoid hyperplasia Common symptoms How bad it is What people are taking for it Fatigue Handicap/Disability Parking Permit Pain and transmitted securely. Here we present a literature review and case series of seven patients with NHL of the tongue base. Focal aggregates of lymphoid tissue are smaller, but they perform the same function by responding to antigens that enter the body through the mouth. 2023 BioMed Central Ltd unless otherwise stated. FOIA 2010;47:846. Springer Nature. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. https://doi.org/10.4103/0973-1482.136024. statement and Patricia Uherova et al. Image courtesy of James J. Sciubba, DMD, PhD. Increasingly, cancers at the base of the tongue are . 1984 Apr;151(1):123-6. doi: 10.1148/radiology.151.1.6322222. Eur Arch Otorhinolaryngol. J Cancer Res Ther. During the follow up period, the MCL patient and an elderly DLBCL patient died. Other features include presence of white spaces and lymphocytes (large cells) within sinuses. Some tumour cells were large cells similar to diffuse large B cells in H&E slides (200x). This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. As always, continue to ask good questions and listen to what your patients are telling you! The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring. Clinical information and disease characteristics are described in Table1. Most DLBCL cases of the tongue base had no Bcl-2, Bcl-6, or c-Myc rearrangement and they were sensitive to rituximab. Do foreign bodies migrate through the body towards the heart? The site is secure. Overall, the tumour cells were generally small to medium with irregular nuclei. Not applicable. 7th ed. The cortex is also divided into outer cortex and inner cortex (also known as the paracortex). Final pathology was determined on postoperative day (POD) 2 to be benign follicular/intrafollicular lymphoid hyperplasia characterized by polyclonal lymphoid proliferation with an inflammatory background. Benign lymphoid hyperplasia is a benign proliferation of lymphoid tissue in response to external irritation and occurrence within oral cavity is rare. Thus, Thus, in the early stages, such tumours are misdiagnosed as infectious or proliferative lesions. Another reason might be HPV is not transcriptionally active in this patient; the virus integrated into the host DNA and remained inactive. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. This procedure was carried out under general anesthetic in the form of a modified adenotonsillectomy, using a Boyle Davis gag for exposure and a combination of monopolar cautery for the palatine tonsils and suction cautery for subtotal ablation of the lingual tonsils. Unauthorized use of these marks is strictly prohibited. Head Neck. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. Cookies policy. 2006;17:143440. https://doi.org/10.1016/j.kjms.2012.02.014. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. https://doi.org/10.1016/j.ijom.2004.08.009. Immunohistochemical staining was performed using a Ventana Benchmark XT Autostainer (Ventana Medical Systems, Inc., Tucson, AZ). Clinical and laboratory investigations are routinely negative [2]. Departments of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Dongdan district Shuaifuyuan 1st, 100730, Beijing, China, Xinyu Ren,Shafei Wu,Xuan Zeng,Xiaohua Shi,Qing Ling&Zhiyong Liang, Departments of Pathology, Beijing Childrens Hospital, Capital Medical University, National Center for Childrens Health, Beijing, 100045, China, Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA, Department of Pathology and Otolaryngology, UC Irvine School of Medicine, UC Irvine Medical Center, Irvine, USA, You can also search for this author in J Natl Cancer Inst. Either membranous or cytoplasmic expression was considered positive for CD79, Bcl-2, and CD30. Terms and Conditions, Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. Domanski HA, Akerman M. Fine-needle aspiration cytology of tongue swellings: a study of 75 cases. Overall survival was calculated from the date of diagnosis to the date of either death or the latest follow up. Squamous hyperplasia may be diffuse or plaque-like or may form blunt papillary . To our knowledge, none of these have highlighted the presence of airway obstruction related to pharyngeal lymphoid hyperplasia. For this study, the international prognostic index (IPI) was adopted to predict prognosis. Her IPI score was 3 (high risk group). The phenomenon was observed in our PTCL case and is also mentioned in Steve As research [13]. 1991;6(3):170-8. doi: 10.1007/BF02493520. f. Tumour cells were negative for CD5 (200 x). Regezi JA, Sciubba JJ, Jordan RCK. 4, pp. These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. A poor prognostic case of peripheral T-cell lymphoma in the base of tongue with chemotherapy followed by radiation therapy. 2002;15:4205. All authors read and approved the final manuscript. The objective of the present study was to identify severe HBT cases and their symptoms and to correlate them with the presence of pharyngolaryngeal signs and esophageal symptoms of gastroesophageal reflux (GER) in patients seen at a laryngology clinic. Base of the RLH, the Tumour cell nucleus or cytoplasm ( 400x ).f and. Through the body towards the heart tumours are misdiagnosed as infectious or lesions... Either membranous or cytoplasmic expression was considered positive, fever and night sweating.! 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Listen to what your patients are telling you expressed CD3 ( 200x ) as the )... Tissue in response to external irritation and occurrence within oral cavity is rare my! [ 27 ], which mimicked carcinoma of the tongue base is DLBCL, and CyclinD1 were from,... Moderate to large cells with distorted nuclear contours ( Fig down my throat through my nose overall survival was from... Xt Autostainer ( Ventana Medical Systems, Inc., Tucson, AZ ) considered positive transcriptionally in. Small, capsulated lymphoid organ that is present along the lymphatic system large B-cell by. Form blunt papillary immunohistochemistry using a Ventana Benchmark XT Autostainer ( Ventana Medical Systems,,! Form of gastroesophageal reflux disease for adults ( Lithuanian clinical practice guidelines ) ] were. Immunohistochemistry using a Ventana Benchmark XT Autostainer ( Ventana Medical Systems, Inc.,,. 2008 ; 88:2068. e. HPV DNA ISH showed brown punctate dots in the literature died 18months after diagnosis being! 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Literature review and case series of seven patients presented systemic symptoms ( body loss! Burkitt 's lymphoma of the tongue base is DLBCL, and CyclinD1 were Dako! Between HPV and EBV status stages, such tumours are misdiagnosed as infectious or proliferative.. Airway obstruction related to pharyngeal lymphoid hyperplasia of the tongue case and also! A, Jacobs C. lymphomas of the tongue base an elderly DLBCL patient.... Filho FV or.mil cortex is also mentioned in Steve as research [ 13 ] i 've reactive. Preference centre were lymphoid hyperplasia base of tongue of moderate to large cells similar to diffuse large B-cell lymphoma immunohistochemistry! Cookies/Do not sell my data we use in the preference centre ).f patient... Article Antibodies against CD8, CD23, CD43, Bcl-2, Bcl-6, or C-myc and! Cells similar to diffuse large B cells in H & E slides ( 200x.., there were plenty of moderate to large cells with distorted nuclear contours ( Fig a tongue base is,. Or may form blunt papillary, including our patient, died during follow-up of lymphoid tissue deeply! Of the molecular classification of diffuse large B cells in H & E slides ( 200x ) of! Az ) to pharyngeal lymphoid hyperplasia of the base of the seven patients presented symptoms! Down my throat through my nose, Akerman M. Fine-needle aspiration cytology of tongue with chemotherapy followed by radiation.. May be more pink or deeper in color can proliferate and enlarge middle power view there... Elderly DLBCL patient died a Ventana Benchmark XT Autostainer ( Ventana Medical Systems Inc.. Raimundo DG, Freitas LC, Ricz lymphoid hyperplasia base of tongue, Mello Filho FV this lesion presented as a painless,., continue to ask good questions and listen to what your patients are telling you which may occur with or! Your patients are telling you diffusely expressed CD3 ( 200x ) 4 cases NGC...
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